The effects of a new prokinetic compound, cisapride (R51619), on anterior pituitary secretion were evaLuated in 20 heaLthy voLunteers (10 men and 10 fertiLe women) in a doubLe bLind crossover pLacebo study. Cisapride (5 mg tabLet) and pLacebo, were given oraLLy (3 times a day) for 5 days with one week intervaL. PLasma hormone determinations were done by RIAs. No changes in PRL, LH, FSH, GH, TSH, cortisoL, B-Lipotropin, B-endorphin, testosterone and estradioL pLasma LeveLs were found after both cisapride and pLacebo. These data indicate that cisapride is a safe drug as concerns neuroendocrine effects and its mechanisms of action do not incLude a dopaminergic mediation
CISAPRIDE (R 51619) HAS NO EFFECT ON ANTERIOR PITUITARY SECRETIONS / E., Martignoni; Facchinetti, Fabio; G., Comitini; G., Sances; G., Nappi; A. R., Genazzani. - In: NEUROENDOCRINOLOGY LETTERS. - ISSN 0172-780X. - STAMPA. - 1:(1988), pp. 57-57. (Intervento presentato al convegno . tenutosi a . nel .).
CISAPRIDE (R 51619) HAS NO EFFECT ON ANTERIOR PITUITARY SECRETIONS
FACCHINETTI, Fabio;
1988
Abstract
The effects of a new prokinetic compound, cisapride (R51619), on anterior pituitary secretion were evaLuated in 20 heaLthy voLunteers (10 men and 10 fertiLe women) in a doubLe bLind crossover pLacebo study. Cisapride (5 mg tabLet) and pLacebo, were given oraLLy (3 times a day) for 5 days with one week intervaL. PLasma hormone determinations were done by RIAs. No changes in PRL, LH, FSH, GH, TSH, cortisoL, B-Lipotropin, B-endorphin, testosterone and estradioL pLasma LeveLs were found after both cisapride and pLacebo. These data indicate that cisapride is a safe drug as concerns neuroendocrine effects and its mechanisms of action do not incLude a dopaminergic mediation
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