Brain-targeted polymeric nanoparticles: in vivo evidences after different routes of administration in rodents.

The capacity of polymeric nanoparticles (NPs) to reach the target regardless to the administration route is a neglected field of investigation in the pharmaceutical nanotechnology. Therefore, after having demonstrated in previous studies that glycopeptide-engineered NPs (g7-NPs) were able to reach the brain after intravenous administrations in rodents, this paper aimed to evaluate if they can reach the Central Nervous System (CNS) also when administered by different routes. The confocal microphotographs on murine brain sections showed the capability of g7-NPs to reach the target also after intraperitoneal, intranasal and oral administrations. These highlights could open new vistas to a future application of the g7-NPs in the therapeutic treatments of CNS diseases.