Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene expression is associated with a selective or a preferential inhibition of tumour as compared to normal cell proliferation. Even though numerous studies attest the short-term in vitro efficacy of antisense oligodeoxynucleotides as inhibitors of tumour growth, the use of these compounds as therapeutic agents awaits a more rigorous demonstration of their long term effects and favourable pharmacological properties.

Antisense oligonucleotides / Calabretta, Bruno; Skorski, T; Zon, G.. - In: SEMINARS IN CANCER BIOLOGY. - ISSN 1044-579X. - STAMPA. - 3:(1992), pp. 391-398.

Antisense oligonucleotides.

CALABRETTA, Bruno;
1992

Abstract

Growing evidence indicates that antisense oligodeoxynucleotides can specifically inhibit gene expression thereby providing an essential tool for understanding gene function and the potential to affect abnormal cell proliferation. Because oncogene activation is intimately involved in tumour initiation and progression, down-regulation of oncogene expression is associated with a selective or a preferential inhibition of tumour as compared to normal cell proliferation. Even though numerous studies attest the short-term in vitro efficacy of antisense oligodeoxynucleotides as inhibitors of tumour growth, the use of these compounds as therapeutic agents awaits a more rigorous demonstration of their long term effects and favourable pharmacological properties.
1992
3
391
398
Antisense oligonucleotides / Calabretta, Bruno; Skorski, T; Zon, G.. - In: SEMINARS IN CANCER BIOLOGY. - ISSN 1044-579X. - STAMPA. - 3:(1992), pp. 391-398.
Calabretta, Bruno; Skorski, T; Zon, G.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/811739
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