We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA) gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNA gene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter in equilibrium Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12 in equilibrium 6pter and probably represents a second pseudogene.
Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20 / Ku, Dh; Travali, S; Calabretta, Bruno; Huebner, K; Baserga, R.. - In: SOMATIC CELL AND MOLECULAR GENETICS. - ISSN 0740-7750. - STAMPA. - 15:(1989), pp. 297-307.
Human gene for proliferating cell nuclear antigen has pseudogenes and localizes to chromosome 20.
CALABRETTA, Bruno;
1989
Abstract
We have isolated from a human genomic library a pseudogene of the proliferating cell nuclear antigen (PCNA) gene. Its sequence shows a 78% similarity with the human PCNA/cDNA. The PCNA gene is located on human chromosome 20, while the pseudogene maps to chromosome region Xpter in equilibrium Xq13. An additional locus detected by the full-length PCNA cDNA, but not by intron probes, segregates concordantly with chromosome region 6p12 in equilibrium 6pter and probably represents a second pseudogene.
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