The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin / Jaskulski, D; Deriel, Jk; Mercer, We; Calabretta, Bruno; Baserga, R.. - In: SCIENCE. - ISSN 1095-9203. - STAMPA. - 240:(1988), pp. 1544-1546.
Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin.
CALABRETTA, Bruno;
1988
Abstract
The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression
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