The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified alpha-, beta- or gamma-cyclodextrins was investigated in water by phase-solubility analysis. Among the available cyclodextrins, only hydroxypropyl-beta-cyclodextrin (HP-beta-CD) produced a significant increase in the aqueous solubility of BM-DBM. The complexation of the sunscreen agent with HP-beta-CD was studied by circular dichroism, differential scanning calorimetry and X-ray diffractometry. The data from the solubility and the circular dichroism studies suggested the formation of a 1:2 (sunscreen:cyclodextrin) complex. The photodegradation of BM-DBM was reduced by inclusion complexation with HP-beta-CD. Therefore the complex can be used to improve the photostability of the sunscreen agent. (C) 1998 Elsevier Science B.V. All rights reserved.

Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-beta-cyclodextrin / Scalia, S; Villani, S; Scatturin, A; Vandelli, Maria Angela; Forni, Flavio. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 175:(1998), pp. 205-213.

Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-beta-cyclodextrin.

VANDELLI, Maria Angela;FORNI, Flavio
1998

Abstract

The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified alpha-, beta- or gamma-cyclodextrins was investigated in water by phase-solubility analysis. Among the available cyclodextrins, only hydroxypropyl-beta-cyclodextrin (HP-beta-CD) produced a significant increase in the aqueous solubility of BM-DBM. The complexation of the sunscreen agent with HP-beta-CD was studied by circular dichroism, differential scanning calorimetry and X-ray diffractometry. The data from the solubility and the circular dichroism studies suggested the formation of a 1:2 (sunscreen:cyclodextrin) complex. The photodegradation of BM-DBM was reduced by inclusion complexation with HP-beta-CD. Therefore the complex can be used to improve the photostability of the sunscreen agent. (C) 1998 Elsevier Science B.V. All rights reserved.
1998
175
205
213
Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-beta-cyclodextrin / Scalia, S; Villani, S; Scatturin, A; Vandelli, Maria Angela; Forni, Flavio. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 175:(1998), pp. 205-213.
Scalia, S; Villani, S; Scatturin, A; Vandelli, Maria Angela; Forni, Flavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/8112
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