The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified alpha-, beta- or gamma-cyclodextrins was investigated in water by phase-solubility analysis. Among the available cyclodextrins, only hydroxypropyl-beta-cyclodextrin (HP-beta-CD) produced a significant increase in the aqueous solubility of BM-DBM. The complexation of the sunscreen agent with HP-beta-CD was studied by circular dichroism, differential scanning calorimetry and X-ray diffractometry. The data from the solubility and the circular dichroism studies suggested the formation of a 1:2 (sunscreen:cyclodextrin) complex. The photodegradation of BM-DBM was reduced by inclusion complexation with HP-beta-CD. Therefore the complex can be used to improve the photostability of the sunscreen agent. (C) 1998 Elsevier Science B.V. All rights reserved.
Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-beta-cyclodextrin / Scalia, S; Villani, S; Scatturin, A; Vandelli, Maria Angela; Forni, Flavio. - In: INTERNATIONAL JOURNAL OF PHARMACEUTICS. - ISSN 0378-5173. - STAMPA. - 175:(1998), pp. 205-213.
Complexation of the sunscreen agent, butyl-methoxydibenzoylmethane, with hydroxypropyl-beta-cyclodextrin.
VANDELLI, Maria Angela;FORNI, Flavio
1998
Abstract
The interaction between the sunscreen, butyl-methoxydibenzoylmethane (BM-DBM), and parent and modified alpha-, beta- or gamma-cyclodextrins was investigated in water by phase-solubility analysis. Among the available cyclodextrins, only hydroxypropyl-beta-cyclodextrin (HP-beta-CD) produced a significant increase in the aqueous solubility of BM-DBM. The complexation of the sunscreen agent with HP-beta-CD was studied by circular dichroism, differential scanning calorimetry and X-ray diffractometry. The data from the solubility and the circular dichroism studies suggested the formation of a 1:2 (sunscreen:cyclodextrin) complex. The photodegradation of BM-DBM was reduced by inclusion complexation with HP-beta-CD. Therefore the complex can be used to improve the photostability of the sunscreen agent. (C) 1998 Elsevier Science B.V. All rights reserved.
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