We measured CSF and plasma contents of beta-endorphin (beta-EP), beta-lipotropin (beta-LPH), and ACTH in 24 patients with Parkinson's disease; 14 had not been treated. CSF beta-EP concentrations in untreated patients were lower than in 15 controls (p less than 0.005), but values did not differ significantly in treated and untreated patients. In untreated and treated patients, ACTH and beta-LPH CSF, and beta-EP, beta-LPH, and ACTH plasma concentrations were in the same range as controls. The Parkinson's disease-related decrease of CSF beta-EP levels further supports the concept that there is a generalized brain disorder in Parkinson's disease affecting more than dopaminergic neurons in the substantia nigra.

beta-Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients / G., Nappi; F., Petraglia; E., Martignoni; Facchinetti, Fabio; G., Bono; A. R., Genazzani. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 35:(1985), pp. 1371-1374.

beta-Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients.

FACCHINETTI, Fabio;
1985

Abstract

We measured CSF and plasma contents of beta-endorphin (beta-EP), beta-lipotropin (beta-LPH), and ACTH in 24 patients with Parkinson's disease; 14 had not been treated. CSF beta-EP concentrations in untreated patients were lower than in 15 controls (p less than 0.005), but values did not differ significantly in treated and untreated patients. In untreated and treated patients, ACTH and beta-LPH CSF, and beta-EP, beta-LPH, and ACTH plasma concentrations were in the same range as controls. The Parkinson's disease-related decrease of CSF beta-EP levels further supports the concept that there is a generalized brain disorder in Parkinson's disease affecting more than dopaminergic neurons in the substantia nigra.
1985
35
1371
1374
beta-Endorphin cerebrospinal fluid decrease in untreated parkinsonian patients / G., Nappi; F., Petraglia; E., Martignoni; Facchinetti, Fabio; G., Bono; A. R., Genazzani. - In: NEUROLOGY. - ISSN 0028-3878. - STAMPA. - 35:(1985), pp. 1371-1374.
G., Nappi; F., Petraglia; E., Martignoni; Facchinetti, Fabio; G., Bono; A. R., Genazzani
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/809090
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 55
  • ???jsp.display-item.citation.isi??? 54
social impact