L-Tryptophan (L-TP) has been used in migraine and other pain conditions. The mechanism underlying the analgesic effect is still partly undefined. In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. To measure also an objective indicator for pain, the nociceptive flexion reflex threshold was studied. L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05). L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone. Neither subjective pain threshold and tolerance nor RIII threshold was modified by either treatment. Our data seem to point to the existence of a complex linkage between plasma opioid levels and pain perception.

Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis / A. R., Genazzani; G., Sandrini; Facchinetti, Fabio; V., Rizzo; E., Alfonsi; G., Sances; M., Calvani; G., Nappi. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 6:(1986), pp. 241-245.

Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis.

G. Sandrini;FACCHINETTI, Fabio;
1986

Abstract

L-Tryptophan (L-TP) has been used in migraine and other pain conditions. The mechanism underlying the analgesic effect is still partly undefined. In this study the effects of subchronic administration of L-5-hydroxy-tryptophan (L-5HTP) (with and without carbidopa) on plasma beta-endorphin (beta-EP) levels and subjective pain threshold and tolerance were investigated in seven healthy volunteers. To measure also an objective indicator for pain, the nociceptive flexion reflex threshold was studied. L-5HTP treatment with and without carbidopa administration increased beta-EP levels significantly (p less than 0.05). L-5HTP plus carbidopa induced an increase in beta-EP significantly (p less than 0.05) higher than that after L-5HTP alone. Neither subjective pain threshold and tolerance nor RIII threshold was modified by either treatment. Our data seem to point to the existence of a complex linkage between plasma opioid levels and pain perception.
1986
6
241
245
Effects of L-5HTP with and without carbidopa on plasma beta-endorphin and pain perception. Possible implications in migraine prophylaxis / A. R., Genazzani; G., Sandrini; Facchinetti, Fabio; V., Rizzo; E., Alfonsi; G., Sances; M., Calvani; G., Nappi. - In: CEPHALALGIA. - ISSN 0333-1024. - STAMPA. - 6:(1986), pp. 241-245.
A. R., Genazzani; G., Sandrini; Facchinetti, Fabio; V., Rizzo; E., Alfonsi; G., Sances; M., Calvani; G., Nappi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/808299
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