Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.
N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia / G., Nappi; Facchinetti, Fabio; E., Martignoni; F., Petraglia; E., Sinforiani; G., Bono; A. R., Genazzani. - In: ACTA NEUROLOGICA SCANDINAVICA. - ISSN 0001-6314. - STAMPA. - 78:(1988), pp. 146-151.
N-terminal ACTH fragments increase the CSF beta-EP content in Alzheimer type dementia.
FACCHINETTI, Fabio;
1988
Abstract
Eleven patients with presenile Alzheimer type dementia (ATD) were treated with N-terminal ACTH fragments for 14 days. No change in cognitive functions was observed during the treatment. A significant increase in CSF beta-endorphin (beta-EP) levels was found, while ACTH and beta-lipoprotein remain unaffected. The possibility that ACTH and its moieties could interfere with beta-EP activities in CNS is discussed.
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