The seeds of Griffonia simplicifolia Baill. are rich in 5-HIP (5-hydroxytryptophan), a direct precursor of the neurotransmitter serotonin. In the present study we investigated the influence of the plant extract on male sexual behavior. The seed extract was orally administered to Sprague-Dawley male rats at three dose levels (25, 50 and 100 mg/kg) both acutely and subchronically (daily for 9 days). Mating test with receptive female rats was performed 60 min after the acute treatment or the last dose when repetitively administered. Mount, intromission and ejaculation latencies and post-ejaculatory interval were recorded. Food intake and body weight were measured over the 9-day period of treatment. Microdialysis technique was used to detect the extracellular levels of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in rat brain following the acute administration of the extract dosed at 100 mg/kg. The acute treatment significantly increased mount latency (at any dosage), intromission and ejaculation latencies (at 100 mg/kg) and post-ejaculatory interval (at 50 and 100 mg/kg). On the contrary the subchronic treatment failed to exert a significant influence on copulatory behavior. The daily administration of the extract dosed at 50 and 100 mg/kg for 9 days significantly reduced food intake and body weight. Finally in the microdialysis experiments we found a dramatic increase in 5-HT and its metabolite 5-HIAA. (C) 2011 Elsevier GmbH. All rights reserved.

Influence of Griffonia simplicifolia on male sexual behavior in rats: Behavioral and neurochemical study / Carnevale, Gianluca; V. D., Viesti; Zavatti, Manuela; A., Benelli; P., Zanoli. - In: PHYTOMEDICINE. - ISSN 0944-7113. - STAMPA. - 18:11(2011), pp. 947-952. [10.1016/j.phymed.2011.02.009]

Influence of Griffonia simplicifolia on male sexual behavior in rats: Behavioral and neurochemical study

CARNEVALE, Gianluca;ZAVATTI, Manuela;
2011

Abstract

The seeds of Griffonia simplicifolia Baill. are rich in 5-HIP (5-hydroxytryptophan), a direct precursor of the neurotransmitter serotonin. In the present study we investigated the influence of the plant extract on male sexual behavior. The seed extract was orally administered to Sprague-Dawley male rats at three dose levels (25, 50 and 100 mg/kg) both acutely and subchronically (daily for 9 days). Mating test with receptive female rats was performed 60 min after the acute treatment or the last dose when repetitively administered. Mount, intromission and ejaculation latencies and post-ejaculatory interval were recorded. Food intake and body weight were measured over the 9-day period of treatment. Microdialysis technique was used to detect the extracellular levels of serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA) in rat brain following the acute administration of the extract dosed at 100 mg/kg. The acute treatment significantly increased mount latency (at any dosage), intromission and ejaculation latencies (at 100 mg/kg) and post-ejaculatory interval (at 50 and 100 mg/kg). On the contrary the subchronic treatment failed to exert a significant influence on copulatory behavior. The daily administration of the extract dosed at 50 and 100 mg/kg for 9 days significantly reduced food intake and body weight. Finally in the microdialysis experiments we found a dramatic increase in 5-HT and its metabolite 5-HIAA. (C) 2011 Elsevier GmbH. All rights reserved.
2011
18
11
947
952
Influence of Griffonia simplicifolia on male sexual behavior in rats: Behavioral and neurochemical study / Carnevale, Gianluca; V. D., Viesti; Zavatti, Manuela; A., Benelli; P., Zanoli. - In: PHYTOMEDICINE. - ISSN 0944-7113. - STAMPA. - 18:11(2011), pp. 947-952. [10.1016/j.phymed.2011.02.009]
Carnevale, Gianluca; V. D., Viesti; Zavatti, Manuela; A., Benelli; P., Zanoli
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/802090
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 3
social impact