Using an in vitro experimental model, we have recently demonstrated that Candida albicans in its hyphal form (H-Candida), similarly to lipopolysaccharide (LPS), enhances tumor necrosis factor (TNF) secretory response in the cloned macrophage (M phi) population ANA-1. Here we show that H-Candida and LPS each differ in their requirements for intact protein kinase functions, susceptibility to 0.4-microns micropore-size membranes, and sensitivity to polymyxin B. These results, together with the synergistic effect occurring between H-Candida and LPS in inducing TNF response, indicate the existence of different receptor(s) and/or signal-transduction pathway(s) through which the two stimuli act.

Different events involved in the induction of macrophage tumor necrosis factor by Candida albicans and lipopolysaccharide / Blasi, Elisabetta; Pitzurra, L; Puliti, M; Mazzolla, R; Barluzzi, R; Saleppico, S; Bistoni, F.. - In: CELLULAR IMMUNOLOGY. - ISSN 0008-8749. - ELETTRONICO. - 157 (2):(1994), pp. 501-509.

Different events involved in the induction of macrophage tumor necrosis factor by Candida albicans and lipopolysaccharide.

BLASI, Elisabetta;
1994-01-01

Abstract

Using an in vitro experimental model, we have recently demonstrated that Candida albicans in its hyphal form (H-Candida), similarly to lipopolysaccharide (LPS), enhances tumor necrosis factor (TNF) secretory response in the cloned macrophage (M phi) population ANA-1. Here we show that H-Candida and LPS each differ in their requirements for intact protein kinase functions, susceptibility to 0.4-microns micropore-size membranes, and sensitivity to polymyxin B. These results, together with the synergistic effect occurring between H-Candida and LPS in inducing TNF response, indicate the existence of different receptor(s) and/or signal-transduction pathway(s) through which the two stimuli act.
157 (2)
501
509
Different events involved in the induction of macrophage tumor necrosis factor by Candida albicans and lipopolysaccharide / Blasi, Elisabetta; Pitzurra, L; Puliti, M; Mazzolla, R; Barluzzi, R; Saleppico, S; Bistoni, F.. - In: CELLULAR IMMUNOLOGY. - ISSN 0008-8749. - ELETTRONICO. - 157 (2):(1994), pp. 501-509.
Blasi, Elisabetta; Pitzurra, L; Puliti, M; Mazzolla, R; Barluzzi, R; Saleppico, S; Bistoni, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/776291
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