Functional inactivation of Mismatch Repair (MMR) genes by mutations or epigenetic mechanisms favors the acquisition of mutations in 'target genes'. We analysed 94 colorectal cancer (CRC) with microsatellite instability-high (MSI-H) for the presence of mutations in microsatellites located in the coding regiobns (CDRs) of 6 geens: TGF; RII, BAX, hMLH3, hMSH6, MBD4 and BLM.
Different involvement of target genes mutations in hereditary and sporadic colorectal cancer with Microsatellite Instability / Borghi, F; Pedroni, Monica; Lamberti, I; Menigatti, M; Ponti, Giovanni; Rossi, G; Di Gregorio, C; Losi, Lorena; Scarselli, A; Benatti, P; Roncucci, Luca; PONZ DE LEON, Maurizio. - In: FAMILIAL CANCER. - ISSN 1389-9600. - STAMPA. - 2:(2003), pp. 57-58.
Different involvement of target genes mutations in hereditary and sporadic colorectal cancer with Microsatellite Instability.
Borghi F;PEDRONI, Monica;PONTI, Giovanni;LOSI, Lorena;RONCUCCI, Luca;PONZ DE LEON, Maurizio
2003
Abstract
Functional inactivation of Mismatch Repair (MMR) genes by mutations or epigenetic mechanisms favors the acquisition of mutations in 'target genes'. We analysed 94 colorectal cancer (CRC) with microsatellite instability-high (MSI-H) for the presence of mutations in microsatellites located in the coding regiobns (CDRs) of 6 geens: TGF; RII, BAX, hMLH3, hMSH6, MBD4 and BLM.
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