BACKGROUND: Differentiating steatosis from NASH is key in deciding treatment and follow-up schedules. We hypothesized that sonographic grading of steatosis willcorrelate with metabolic and pathologic changes of NASH.METHODS: Fifty-three non-consecutive patients had a semi-quantitative evaluation of hepatic steatosis through ultrasonographic Fatty Liver Indicator (US-FLI) justprior to liver biopsy. All biopsies demonstrated NAFLD. US-FLI is a new scoring system ranging 2-8 based on the intensity of liver/kidney contrast, posterior attenuation of ultrasound beam, vessel blurring, difficult visualization of gallbladder wall, difficult visualization of the diaphragm and areas of focalsparing. NAFLD is diagnosed by the minimum score ≥2. Ultrasonographic findings were correlated with metabolic and histological data. Inter-observer US-FLI scoreagreement, evaluated by three different operators in 31 consecutive patients with steatosis, showed "almost perfect/substantial" agreement (P < 0.001).RESULTS: US-FLI showed a positive correlation with HOMA, insulin, uric acid, ferritin, ALT and bilirubin and was associated with steatosis extent assessed histologically and histological features of NASH, except for fibrosis. US-FLI was an independent predictor of NASH (OR 2.236; P = 0.007) and a US-FLI < 4 had ahigh negative predictive value (94%) in ruling out the diagnosis of severe NASH according to Kleiner's criteria.CONCLUSION: Data confirm the hypothesis that US-FLI significantly correlates with metabolic derangements and individual pathologic criteria for NASH and may betterselect patients for liver biopsy.
|Data di pubblicazione:||2012|
|Titolo:||Ultrasonographic fatty liver indicator, a novel score which rules out NASH and is correlated with metabolic parameters in NAFLD.|
|Autore/i:||S. Ballestri; A. Lonardo ; D. Romagnoli ;L. Carulli;L Losi ; CP Day ; P Loria .|
|Digital Object Identifier (DOI):||10.1111/j.1478-3231.2012.02804.x|
|Codice identificativo ISI:||WOS:000307722000008|
|Codice identificativo Scopus:||2-s2.0-84865191383|
|Codice identificativo Pubmed:||22520641|
|Citazione:||Ultrasonographic fatty liver indicator, a novel score which rules out NASH and is correlated with metabolic parameters in NAFLD. / S. Ballestri; A. Lonardo ; D. Romagnoli ;L. Carulli;L Losi ; CP Day ; P Loria .. - In: LIVER INTERNATIONAL. - ISSN 1478-3223. - STAMPA. - 32(2012), pp. 1242-1252.|
|Tipologia||Articolo su rivista|
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