BACKGROUND: Two-thirds of colorectal malignancies are localised in the left colon and rectum. Recent studies suggest a trend towards an increase of right-sided tumours which might have important implications for screening and surveillance. A colorectal cancer registry was set up in Modena, northern Italy, with the purpose of examining incidence, subsite distribution and staging of colorectal malignancies over a 15-year period.PATIENTS AND METHODS: From 1984 to 1998, 2517 tumours in 2462 patients were detected and staged with the tumour node metastasis (TNM) system. The 'right colon' was considered from caecum to splenic flexure; the 'left colon' included descending and sigmoid colon; and the 'rectum' included rectosigmoid junction, ampulla and anus.RESULTS: Cancer incidence showed an overall increase. Considering the various subsites, an increase of 33.7% in all colonic segments was shown whereas rectal tumours tended to decline. TNM staging showed a gradual increase of localised lesions (41.2% in 1984 versus 53.3% in 1998), with a proportional reduction of advanced tumours.CONCLUSIONS: Our study indicates an increase of tumour incidence in all colonic segments more than a shift to the right colon. TNM staging tended to improve with an appreciable increase of localised lesions. These findings could be consequent to a more extensive use of colonoscopy.
|Data di pubblicazione:||2004|
|Titolo:||Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry.|
|Autore/i:||Ponz de Leon M; Marino M; Benatti P; Rossi G; Menigatti M; Pedroni M; Di Gregorio C; Losi L; Borghi F; Scarselli A; Ponti G; Roncari B; Zangardi G; Abbati G; Ascari E; Roncucci L|
|Digital Object Identifier (DOI):||10.1093/annonc/mdh224|
|Codice identificativo ISI:||WOS:000222369700016|
|Codice identificativo Scopus:||2-s2.0-3442888868|
|Codice identificativo Pubmed:||15151952|
|Citazione:||Trend of incidence, subsite distribution and staging of colorectal neoplasms in the 15-year experience of a specialised cancer registry. / Ponz de Leon M; Marino M; Benatti P; Rossi G; Menigatti M; Pedroni M; Di Gregorio C; Losi L; Borghi F; Scarselli A; Ponti G; Roncari B; Zangardi G; Abbati G; Ascari E; Roncucci L. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - STAMPA. - 15(2004), pp. 940-946.|
|Tipologia||Articolo su rivista|
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