BACKGROUND: Metabolic complications, including type 2 diabetes mellitus and metabolic syndrome, are increasingly recognized among HIV-infected individuals. Low vitamin D levels increase the risk of type 2 diabetes mellitus, and vitamin D supplementation has been shown to decrease the risk of type 2 diabetes mellitus in patients without HIV infection.OBJECTIVES: The primary objective was to determine whether vitamin D deficiency (serum 25-hyrdoxyvitamin D <20 ng/ml) was associated with type 2 diabetes mellitus among HIV-infected patients. Our secondary objective was to determine whether vitamin D deficiency was associated with metabolic syndrome in HIV.METHODS: We conducted a cross-sectional study among participants enrolled in the prospective Modena (Italy) HIV Metabolic Clinic Cohort. Clinical and laboratory data, including history of type 2 diabetes mellitus, fasting blood glucose, components of metabolic syndrome, and 25-hydroxyvitamin D levels, were obtained for all participants.RESULTS: After adjusting for vitamin D supplementation, sex, age, body mass index, and hepatitis C virus co-infection, vitamin D deficiency was associated with type 2 diabetes mellitus [adjusted odds ratio (OR) 1.85; 95% confidence interval (CI) 1.03-3.32; P = 0.038]. The association between vitamin D deficiency and metabolic syndrome was not significant after adjusting for vitamin D supplementation, sex, age and body mass index (adjusted OR 1.32; 95% CI 1.00-1.75; P = 0.053).CONCLUSIONS: Our study demonstrates an association between vitamin D deficiency and type 2 diabetes mellitus. Clinical trials are needed to better characterize the association between vitamin D deficiency and type 2 diabetes mellitus in HIV infection and to evaluate whether vitamin D is able to prevent or delay the onset of type 2 diabetes mellitus.
|Data di pubblicazione:||2011|
|Titolo:||Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection.|
|Autore/i:||Szep Z;Guaraldi G;Shah SS;Lo Re V 3rd;Ratcliffe SJ;Orlando G;Carli F;Rossi R;Rochira V;Tebas P|
|Digital Object Identifier (DOI):||10.1097/QAD.0b013e328342fdfd|
|Codice identificativo ISI:||WOS:000286970300015|
|Codice identificativo Scopus:||2-s2.0-79951516278|
|Codice identificativo Pubmed:||21178753|
|Citazione:||Vitamin D deficiency is associated with type 2 diabetes mellitus in HIV infection. / Szep Z;Guaraldi G;Shah SS;Lo Re V 3rd;Ratcliffe SJ;Orlando G;Carli F;Rossi R;Rochira V;Tebas P. - In: AIDS. - ISSN 0269-9370. - STAMPA. - 25(2011), pp. 525-529.|
|Tipologia||Articolo su rivista|
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