The macromolecular RNA metabolism of the HL-60 promyelocytic cell line was studied after labelling with 3H-5 uridine and sedimentation in a linear sucrose gradient. The pattern obtained in exponentially growing HL-60 cells is strictly similar to that observed in resting circulating leukemic cells, whereas cleavage of early transcripts is very rapid in HeLa cells.
Characteristics of macromolecular RNA metabolism in leukemic promyelocytes of the HL 60 line / Torelli, Umberto; A., Donelli; G., Franchini; Calabretta, Bruno; Ferrari, Sergio; Narni, Franco; Torelli, Giuseppe; G. P., Bagnara; M. A., Brunelli. - In: IRCS MEDICAL SCIENCE. - ISSN 0305-6805. - STAMPA. - 8:(1980), pp. 443-443.
Characteristics of macromolecular RNA metabolism in leukemic promyelocytes of the HL 60 line
TORELLI, Umberto;CALABRETTA, Bruno;FERRARI, Sergio;NARNI, Franco;TORELLI, Giuseppe;
1980
Abstract
The macromolecular RNA metabolism of the HL-60 promyelocytic cell line was studied after labelling with 3H-5 uridine and sedimentation in a linear sucrose gradient. The pattern obtained in exponentially growing HL-60 cells is strictly similar to that observed in resting circulating leukemic cells, whereas cleavage of early transcripts is very rapid in HeLa cells.
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