The primary product of transcription, the heterogeneous nuclear RNA, is processed at a very low rate in leukemic blast cells. The proportion of double-helical segments, presumably the recognition sites of cleaving enzymes, is much greater. An alteration of the mechanisms dictating the formation of secondary structure in heterogeneous nuclear RNA might cause the inhibition of genome expression in leukemic cells.

The primary product of DNA transcription in the blast cell of acute leukemia. Its characterization as an approach to the understanding of the origin of the blast crisis of chronic myeloid leukemia / Torelli, Umberto; Torelli, Giuseppe; Cadossi, Ruggero; Ferrari, Stefano; Ferrari, Sergio; Montagna, G; Narni, Franco; Franchini, G; Donelli, A.. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - STAMPA. - 57:(1978), pp. 325-333.

The primary product of DNA transcription in the blast cell of acute leukemia. Its characterization as an approach to the understanding of the origin of the blast crisis of chronic myeloid leukemia

TORELLI, Umberto;TORELLI, Giuseppe;CADOSSI, Ruggero;FERRARI, Stefano;FERRARI, Sergio;NARNI, Franco;
1978

Abstract

The primary product of transcription, the heterogeneous nuclear RNA, is processed at a very low rate in leukemic blast cells. The proportion of double-helical segments, presumably the recognition sites of cleaving enzymes, is much greater. An alteration of the mechanisms dictating the formation of secondary structure in heterogeneous nuclear RNA might cause the inhibition of genome expression in leukemic cells.
1978
57
325
333
The primary product of DNA transcription in the blast cell of acute leukemia. Its characterization as an approach to the understanding of the origin of the blast crisis of chronic myeloid leukemia / Torelli, Umberto; Torelli, Giuseppe; Cadossi, Ruggero; Ferrari, Stefano; Ferrari, Sergio; Montagna, G; Narni, Franco; Franchini, G; Donelli, A.. - In: BOLLETTINO DELL'ISTITUTO SIEROTERAPICO MILANESE. - ISSN 0021-2547. - STAMPA. - 57:(1978), pp. 325-333.
Torelli, Umberto; Torelli, Giuseppe; Cadossi, Ruggero; Ferrari, Stefano; Ferrari, Sergio; Montagna, G; Narni, Franco; Franchini, G; Donelli, A.
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