EnglishA one-electron reductive metabolism of 1,2-dibromoethane (DBE) is described that gives rise to a free radical intermediate, which can be stabilized by a spin trapping agent and detected by electron spin resonance spectroscopy. Using rat liver microsomes or isolated hepatocytes from phenobarbitone pretreated animals, under hypoxic conditions, it has been possible to trap a free radical intermediate and identify it by using 13C-DBE. Inhibition experiments have demonstrated that the site of activation is the microsomal drug metabolizing system.
Metabolic activation of 1,2-dibromoethane to a free radical intermediate by rat liver microsomes and isolated hepatocytes / Tomasi, Aldo; Albano, Emanuele; M., Dianzani; T., Slater; Vannini, Vanio. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 160(1983), pp. 191-194.
| Data di pubblicazione: | 1983 |
| Titolo: | Metabolic activation of 1,2-dibromoethane to a free radical intermediate by rat liver microsomes and isolated hepatocytes |
| Autore/i: | Tomasi, Aldo; Albano, Emanuele; M., Dianzani; T., Slater; Vannini, Vanio |
| Autore/i UNIMORE: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/0014-5793(83)80964-8 |
| Rivista: | |
| Volume: | 160 |
| Pagina iniziale: | 191 |
| Pagina finale: | 194 |
| Codice identificativo ISI: | WOS:A1983RG75100041 |
| Codice identificativo Scopus: | 2-s2.0-0020513047 |
| Codice identificativo Pubmed: | 6350040 |
| Citazione: | Metabolic activation of 1,2-dibromoethane to a free radical intermediate by rat liver microsomes and isolated hepatocytes / Tomasi, Aldo; Albano, Emanuele; M., Dianzani; T., Slater; Vannini, Vanio. - In: FEBS LETTERS. - ISSN 0014-5793. - STAMPA. - 160(1983), pp. 191-194. |
| Tipologia | Articolo su rivista |
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