An in vitro generated BV-2 microglial cell line has been transferred intracerebrally into syngeneic immunocompetent mice prior to local challenge with Candida albicans. The transfer resulted in the establishment of local protection against a lethal dose of C. albicans, which was accompanied by an impairment of yeast growth in the brain and kidneys. Upon histological examination of brain sections from BV-2 cell-pretreated mice, it was found that the size and number of granulomas was reduced as compared to untreated controls receiving Candida alone. These observations provide direct evidence that microglia play a crucial role in the local defense against intracerebral infections.
Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans / Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 32(1991), pp. 249-257.
Data di pubblicazione: | 1991 |
Titolo: | Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans. |
Autore/i: | Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F. |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 32 |
Pagina iniziale: | 249 |
Pagina finale: | 257 |
Codice identificativo ISI: | WOS:A1991FP39400008 |
Codice identificativo Scopus: | 2-s2.0-0025847878 |
Codice identificativo Pubmed: | 2033118 |
Citazione: | Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans / Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 32(1991), pp. 249-257. |
Tipologia | Articolo su rivista |
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