An in vitro generated BV-2 microglial cell line has been transferred intracerebrally into syngeneic immunocompetent mice prior to local challenge with Candida albicans. The transfer resulted in the establishment of local protection against a lethal dose of C. albicans, which was accompanied by an impairment of yeast growth in the brain and kidneys. Upon histological examination of brain sections from BV-2 cell-pretreated mice, it was found that the size and number of granulomas was reduced as compared to untreated controls receiving Candida alone. These observations provide direct evidence that microglia play a crucial role in the local defense against intracerebral infections.

Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans / Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 32:(1991), pp. 249-257.

Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans.

BLASI, Elisabetta;
1991-01-01

Abstract

An in vitro generated BV-2 microglial cell line has been transferred intracerebrally into syngeneic immunocompetent mice prior to local challenge with Candida albicans. The transfer resulted in the establishment of local protection against a lethal dose of C. albicans, which was accompanied by an impairment of yeast growth in the brain and kidneys. Upon histological examination of brain sections from BV-2 cell-pretreated mice, it was found that the size and number of granulomas was reduced as compared to untreated controls receiving Candida alone. These observations provide direct evidence that microglia play a crucial role in the local defense against intracerebral infections.
32
249
257
Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans / Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 32:(1991), pp. 249-257.
Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/746022
Citazioni
  • ???jsp.display-item.citation.pmc??? 14
  • Scopus 33
  • ???jsp.display-item.citation.isi??? 42
social impact