An in vitro generated BV-2 microglial cell line has been transferred intracerebrally into syngeneic immunocompetent mice prior to local challenge with Candida albicans. The transfer resulted in the establishment of local protection against a lethal dose of C. albicans, which was accompanied by an impairment of yeast growth in the brain and kidneys. Upon histological examination of brain sections from BV-2 cell-pretreated mice, it was found that the size and number of granulomas was reduced as compared to untreated controls receiving Candida alone. These observations provide direct evidence that microglia play a crucial role in the local defense against intracerebral infections.

Intracerebral transfer of an in vitro established microglial cell line: local induction of a protective state against lethal challenge with Candida albicans / Blasi, Elisabetta; Mazzolla, R.; Barluzzi, R.; Mosci, P.; Bartoli, A.; Bistoni, F.. - In: JOURNAL OF NEUROIMMUNOLOGY. - ISSN 0165-5728. - ELETTRONICO. - 32(1991), pp. 249-257.

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