The synergistic bactericidal effect of the oxolinic acid-trimethoprim combination has been confirmed on an exponentially growing strain of Escherichia coli, and is paralleled by a synergistic inhibition of 14C-uracil incorporation into the bacterial DNA. These data provide experimental support for the postulate that the synergistic effect of quinolone-trimethoprim combinations, observed both in vitro and in vivo, is due to a complementary blockade of bacterial DNA synthesis.
Oxolinic acid--trimethoprim combination: effects on DNA synthesis and on viability of Escherichia coli / Genedani, Susanna; Castelli, Mario; Foresta, P; Bertolini, Alfio. - In: CHEMOTHERAPY. - ISSN 0009-3157. - STAMPA. - 29:(1983), pp. 24-27.
Oxolinic acid--trimethoprim combination: effects on DNA synthesis and on viability of Escherichia coli.
GENEDANI, Susanna;CASTELLI, Mario;BERTOLINI, Alfio
1983
Abstract
The synergistic bactericidal effect of the oxolinic acid-trimethoprim combination has been confirmed on an exponentially growing strain of Escherichia coli, and is paralleled by a synergistic inhibition of 14C-uracil incorporation into the bacterial DNA. These data provide experimental support for the postulate that the synergistic effect of quinolone-trimethoprim combinations, observed both in vitro and in vivo, is due to a complementary blockade of bacterial DNA synthesis.
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