It is evident that drug specificity can be improved by increasing the number of interactions with the complementary receptor site. Considering that a protein may bear several carboxylic groups, in principle, polycationic compounds could well represent selective ligands for receptor molecules provided the distance separating the nitrogen atoms of polyamine would be fit the distance between the carboxylic groups of the receptors.It is this rationale that served as the basis for development of polymethylene polyamines as selective inhibitors of different neurotransmitter receptors. The highlights of our findings are described.
POLYAMINES: A POSSIBLE “PASSE-PARTOUT” FOR RECEPTOR CHARACTERIZZATION / C., Melchiorre; P., Angeli; Brasili, Livio; D., Giardinà; U., Gulini; M., Pigini; W., Quaglia. - STAMPA. - (1988), pp. 149-???. (Intervento presentato al convegno Actualités de Chemie Therapeutique tenutosi a Slovenia nel 1988).
POLYAMINES: A POSSIBLE “PASSE-PARTOUT” FOR RECEPTOR CHARACTERIZZATION
BRASILI, Livio;
1988
Abstract
It is evident that drug specificity can be improved by increasing the number of interactions with the complementary receptor site. Considering that a protein may bear several carboxylic groups, in principle, polycationic compounds could well represent selective ligands for receptor molecules provided the distance separating the nitrogen atoms of polyamine would be fit the distance between the carboxylic groups of the receptors.It is this rationale that served as the basis for development of polymethylene polyamines as selective inhibitors of different neurotransmitter receptors. The highlights of our findings are described.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
