The results of a study concerning the enantioselectivity of chiral colinergic agonists and antagonists carrying a 1,3-oxathiolane nucleus are reported. Enantiosetrectivity is usually high for agonists and low for antagonists. It can change from tissue to tissue supports the existence of differences amoung muscarinic M2 receptorsComparison of the stereoisomeries of agonist and antagonist interactions suggests that both kinds of ligand interact with a common binding site on the receptor molecu1e.
ENANTIOSELECTIVITY OF CHTRAL CHOLINERGI AGONISTS AND ANTAGONISTS CARRYING A 1,3-OXATHTOLANE NUCLEUSAGONISTS AND ANTAGONTSTS / F., Gualtieri; P., Angeli; Brasili, Livio; M., Giannella; M. T., Picchio; M. N., Romanelli; E., Teodori. - STAMPA. - (1988), pp. 235-???. (Intervento presentato al convegno Recent Advances in Receptor Chemistry tenutosi a Camerino, Italy nel settembre, 1987).
ENANTIOSELECTIVITY OF CHTRAL CHOLINERGI AGONISTS AND ANTAGONISTS CARRYING A 1,3-OXATHTOLANE NUCLEUSAGONISTS AND ANTAGONTSTS
BRASILI, Livio;
1988
Abstract
The results of a study concerning the enantioselectivity of chiral colinergic agonists and antagonists carrying a 1,3-oxathiolane nucleus are reported. Enantiosetrectivity is usually high for agonists and low for antagonists. It can change from tissue to tissue supports the existence of differences amoung muscarinic M2 receptorsComparison of the stereoisomeries of agonist and antagonist interactions suggests that both kinds of ligand interact with a common binding site on the receptor molecu1e.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
