Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment.

Agnati, Luigi Francesco; Fuxe, K; Zoli, Michele; Davalli, Pierpaola; Corti, Arnaldo; Zini, Isabella; Toffano, G.

In male rats, partial hemitransections but not 6-hydroxydopamine (6-OHDA)-induced lesions of the mesostriatal dopamine (DA) pathway produce after 7 days a marked and a modest increase of striatal putrescine and spermidine levels, respectively, on the lesioned side. Following chronic ganglioside GM1 treatment of partially hemitransected rats, an increase of striatal polyamine levels was observed also on the intact side. It is suggested that retrograde cell body changes produced by hemitransection may induce striatal ornithine decarboxylase activity and in this way increase striatal putrescine levels, favoring regenerative mechanisms. The increase of striatal polyamine levels by GM1 treatment on the intact side of both 6-OHDA and mechanically lesioned rats compared with intact unoperated rats may also reflect an increased synthesis of striatal polyamines.

Data di pubblicazione:	1985
Titolo:	Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment.
Autore/i:	Agnati LF; Fuxe K; Zoli M; Davalli P; Corti A; Zini I; Toffano G
Autore/i UNIMORE:	AGNATI, Luigi Francesco Fuxe K ZOLI, Michele DAVALLI, Pierpaola CORTI, Arnaldo ZINI, Isabella Toffano G. mostra contributor esterni nascondi contributor esterni
Rivista:	NEUROSCIENCE LETTERS
Volume:	61
Pagina iniziale:	339
Pagina finale:	344
Codice identificativo ISI:	WOS:A1985AVX5300018
Codice identificativo Scopus:	2-s2.0-0022373507
Citazione:	Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment. / Agnati LF; Fuxe K; Zoli M; Davalli P; Corti A; Zini I; Toffano G. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 61(1985), pp. 339-344.
Tipologia	Articolo su rivista

File in questo prodotto:

Non ci sono file associati a questo prodotto.

Utilizza questo identificativo per citare o creare un link a questo documento:
http://hdl.handle.net/11380/744408

Citazioni

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris