In male rats, partial hemitransections but not 6-hydroxydopamine (6-OHDA)-induced lesions of the mesostriatal dopamine (DA) pathway produce after 7 days a marked and a modest increase of striatal putrescine and spermidine levels, respectively, on the lesioned side. Following chronic ganglioside GM1 treatment of partially hemitransected rats, an increase of striatal polyamine levels was observed also on the intact side. It is suggested that retrograde cell body changes produced by hemitransection may induce striatal ornithine decarboxylase activity and in this way increase striatal putrescine levels, favoring regenerative mechanisms. The increase of striatal polyamine levels by GM1 treatment on the intact side of both 6-OHDA and mechanically lesioned rats compared with intact unoperated rats may also reflect an increased synthesis of striatal polyamines.

Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment / Agnati, Luigi Francesco; Fuxe, K; Zoli, Michele; Davalli, Pierpaola; Corti, Arnaldo; Zini, Isabella; Toffano, G.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 61:(1985), pp. 339-344.

Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment.

AGNATI, Luigi Francesco;ZOLI, Michele;DAVALLI, Pierpaola;CORTI, Arnaldo;ZINI, Isabella;
1985

Abstract

In male rats, partial hemitransections but not 6-hydroxydopamine (6-OHDA)-induced lesions of the mesostriatal dopamine (DA) pathway produce after 7 days a marked and a modest increase of striatal putrescine and spermidine levels, respectively, on the lesioned side. Following chronic ganglioside GM1 treatment of partially hemitransected rats, an increase of striatal polyamine levels was observed also on the intact side. It is suggested that retrograde cell body changes produced by hemitransection may induce striatal ornithine decarboxylase activity and in this way increase striatal putrescine levels, favoring regenerative mechanisms. The increase of striatal polyamine levels by GM1 treatment on the intact side of both 6-OHDA and mechanically lesioned rats compared with intact unoperated rats may also reflect an increased synthesis of striatal polyamines.
61
339
344
Effects of neurotoxic and mechanical lesions of the mesostriatal dopamine pathway on striatal polyamine levels in the rat: modulation by chronic ganglioside GM1 treatment / Agnati, Luigi Francesco; Fuxe, K; Zoli, Michele; Davalli, Pierpaola; Corti, Arnaldo; Zini, Isabella; Toffano, G.. - In: NEUROSCIENCE LETTERS. - ISSN 0304-3940. - STAMPA. - 61:(1985), pp. 339-344.
Agnati, Luigi Francesco; Fuxe, K; Zoli, Michele; Davalli, Pierpaola; Corti, Arnaldo; Zini, Isabella; Toffano, G.
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/744408
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 22
social impact