The present study shows the effects of two different steroid replacement therapies, with conjugated estrogens or with a new synthetic steroid derivative, ORG OD14, on plasma beta-endorphin (beta-EP) and beta-lipotropin (beta-LPH) levels in postmenopausal subjects. Blood samples were collected before treatment and after 1, 2 and 4 months of treatment; a third group of patients was treated with placebo. After 2 months of treatment both groups of patients who underwent steroid supplementation showed circulating levels of beta-EP and beta-LPH higher than basal levels. ORG OD14 treatment increased beta-EP and beta-LPH levels more than conjugated estrogens at the 2nd month of therapy. No further change was found after 4 months. The two drugs were effective in reducing hot flushes and improving physical and psychological symptoms. These data indicate that sex steroids are able to increase beta-EP and beta-LPH secretion in postmenopausal women, with a concomitant relief of climacteric symptoms.
STEROID REPLACEMENT TREATMENT INCREASES BETA-ENDORPHIN AND BETA-LIPOTROPIN PLASMA LEVELS IN POSTMENOPAUSAL WOMEN / Ar, Genazzani; F., Petraglia; Facchinetti, Fabio; A., Grasso; G., Alessandrini; Volpe, Annibale. - In: GYNECOLOGIC AND OBSTETRIC INVESTIGATION. - ISSN 0378-7346. - STAMPA. - 26(2)(1988), pp. 153-159.
Data di pubblicazione: | 1988 |
Titolo: | STEROID REPLACEMENT TREATMENT INCREASES BETA-ENDORPHIN AND BETA-LIPOTROPIN PLASMA LEVELS IN POSTMENOPAUSAL WOMEN. |
Autore/i: | Ar, Genazzani; F., Petraglia; Facchinetti, Fabio; A., Grasso; G., Alessandrini; Volpe, Annibale |
Autore/i UNIMORE: | |
Rivista: | |
Volume: | 26(2) |
Pagina iniziale: | 153 |
Pagina finale: | 159 |
Codice identificativo ISI: | WOS:A1988P998400009 |
Codice identificativo Scopus: | 2-s2.0-0023710361 |
Codice identificativo Pubmed: | 2851506 |
Citazione: | STEROID REPLACEMENT TREATMENT INCREASES BETA-ENDORPHIN AND BETA-LIPOTROPIN PLASMA LEVELS IN POSTMENOPAUSAL WOMEN / Ar, Genazzani; F., Petraglia; Facchinetti, Fabio; A., Grasso; G., Alessandrini; Volpe, Annibale. - In: GYNECOLOGIC AND OBSTETRIC INVESTIGATION. - ISSN 0378-7346. - STAMPA. - 26(2)(1988), pp. 153-159. |
Tipologia | Articolo su rivista |
File in questo prodotto:

I documenti presenti in Iris Unimore sono rilasciati con licenza Creative Commons Attribuzione - Non commerciale - Non opere derivate 3.0 Italia, salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris