Striatal dopamine D1 transmission was studied in rats 7 days after transient (30 min) forebrain ischemia using the 4-vessel occlusion model. The striatal distribution of dopamine D1 ([3H]SCH 23390 binding sites) and D2 ([3H]sulpiride binding sites) receptors as well as the distribution of adenylate cyclase ( [3H]forskolin binding sites) and of the intracytoplasmic dopamine and cAMP-regulated phosphoprotein DARPP-32 related to D1 transmission were analyzed. While the distribution of D2 receptors was unaffected 7 days after the ischemic insult, all the other markers showed a patchy disappearance in the dorsolateral part of the neostriatum. These findings underline the existence of selective multiple deficits in D1 transmission after transient forebrain ischemia in rat striatum.

Transient forebrain ischemia produces multiple deficits in dopamine D1 transmission in the lateral neostriatum of the rat / Benfenati, Fabio; MERLO PICH, Emilio; Grimaldi, R; Zoli, Michele; Fuxe, K; Toffano, G; Agnati, Luigi Francesco. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 498:(1989), pp. 376-380.

Transient forebrain ischemia produces multiple deficits in dopamine D1 transmission in the lateral neostriatum of the rat.

BENFENATI, Fabio;MERLO PICH, Emilio;ZOLI, Michele;AGNATI, Luigi Francesco
1989

Abstract

Striatal dopamine D1 transmission was studied in rats 7 days after transient (30 min) forebrain ischemia using the 4-vessel occlusion model. The striatal distribution of dopamine D1 ([3H]SCH 23390 binding sites) and D2 ([3H]sulpiride binding sites) receptors as well as the distribution of adenylate cyclase ( [3H]forskolin binding sites) and of the intracytoplasmic dopamine and cAMP-regulated phosphoprotein DARPP-32 related to D1 transmission were analyzed. While the distribution of D2 receptors was unaffected 7 days after the ischemic insult, all the other markers showed a patchy disappearance in the dorsolateral part of the neostriatum. These findings underline the existence of selective multiple deficits in D1 transmission after transient forebrain ischemia in rat striatum.
498
376
380
Transient forebrain ischemia produces multiple deficits in dopamine D1 transmission in the lateral neostriatum of the rat / Benfenati, Fabio; MERLO PICH, Emilio; Grimaldi, R; Zoli, Michele; Fuxe, K; Toffano, G; Agnati, Luigi Francesco. - In: BRAIN RESEARCH. - ISSN 0006-8993. - STAMPA. - 498:(1989), pp. 376-380.
Benfenati, Fabio; MERLO PICH, Emilio; Grimaldi, R; Zoli, Michele; Fuxe, K; Toffano, G; Agnati, Luigi Francesco
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/744243
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 46
  • ???jsp.display-item.citation.isi??? 47
social impact