In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxamuscarone (1 a) incorporating alkyl and phenyl substituents at the positions 2 and 5 were synthesizedas model compounds. However, the sharp drop in activity and the lack of discrimination between nicotinic and muicarinic receptors exhibited by thecompounds discourage their further development as affinity reagents
MOLECULAR REQUIREMENTS OF THE ACTIVE SITESOF THE CHOLINERGIC RECEPTORSXVI (x) - Synthesis qnd cholinergic activity ol 2- or 5-alkyl or 5-phenyl--4-methyl-3-oxo-1 -dimethylaminomethylcy clopentane methiodide / M., Pigini; Brasili, Livio. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - STAMPA. - 2:(1981), pp. ??-??.
MOLECULAR REQUIREMENTS OF THE ACTIVE SITESOF THE CHOLINERGIC RECEPTORSXVI (x) - Synthesis qnd cholinergic activity ol 2- or 5-alkyl or 5-phenyl--4-methyl-3-oxo-1 -dimethylaminomethylcy clopentane methiodide.
BRASILI, Livio
1981
Abstract
In order to study the cholinergic receptor through affinitychromatography, some derivatives ol deoxamuscarone (1 a) incorporating alkyl and phenyl substituents at the positions 2 and 5 were synthesizedas model compounds. However, the sharp drop in activity and the lack of discrimination between nicotinic and muicarinic receptors exhibited by thecompounds discourage their further development as affinity reagents
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