Three piperoxan analogues, derived from the opening of the benzodioxane ring and/or replacement of the oxygen atom with the less polar sulfur, were synthesized. The decrease of the -blocking activity found for these compounds showed that the binding site of benzodioxane-like compounds does not accept the substitution with less polar groups.
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CYCLIC AND OPENED THIOANALOGUES OF PIPEROXAN / G., Strappaghetti; Brasili, Livio. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - STAMPA. - 10:(1986), pp. ??-??.
SYNTHESIS AND PHARMACOLOGICAL EVALUATION OF CYCLIC AND OPENED THIOANALOGUES OF PIPEROXAN
BRASILI, Livio
1986
Abstract
Three piperoxan analogues, derived from the opening of the benzodioxane ring and/or replacement of the oxygen atom with the less polar sulfur, were synthesized. The decrease of the -blocking activity found for these compounds showed that the binding site of benzodioxane-like compounds does not accept the substitution with less polar groups.
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