Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in the development of tolerance. In our experimental conditions, no obvious toxicity was observed. These results may suggest for polyamines a role in nociception, and may disclose a new class of analgesic drugs.
Putrescine has analgesic activity, in rats / Genedani, Susanna; Piccinini, Giorgio; Bertolini, Alfio. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 34:(1984), pp. 2407-2412.
Putrescine has analgesic activity, in rats.
GENEDANI, Susanna;PICCININI, Giorgio;BERTOLINI, Alfio
1984
Abstract
Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in the development of tolerance. In our experimental conditions, no obvious toxicity was observed. These results may suggest for polyamines a role in nociception, and may disclose a new class of analgesic drugs.
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