Intraperitoneal injection of putrescine induced dose-related hypothermia in rats. The effect was more pronounced at room temperature (22 degrees C) than in a warm environment (30 degrees C), the maximum hypothermia (-2.64 +/- 0.29 degrees C, 30 min. after treatment) being obtained with the dose of 300 mg/Kg and remaining significant throughout 3 hr of observation. Putrescine also had antipyretic activity, as it significantly reduced pyrogen-induced fever at a dose level (100 mg/Kg i.p.) ineffective in causing hypothermia in normal rats. The hypothermic and antipyretic effects of putrescine were not associated with any obvious sign of toxicity.

Putrescine has hypothermic and antipyretic activity, in rats / Genedani, Susanna; Bernardi, Mara; Tagliavini, S; Bertolini, Alfio. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 38:(1986), pp. 1293-1298.

Putrescine has hypothermic and antipyretic activity, in rats.

GENEDANI, Susanna;BERNARDI, Mara;BERTOLINI, Alfio
1986

Abstract

Intraperitoneal injection of putrescine induced dose-related hypothermia in rats. The effect was more pronounced at room temperature (22 degrees C) than in a warm environment (30 degrees C), the maximum hypothermia (-2.64 +/- 0.29 degrees C, 30 min. after treatment) being obtained with the dose of 300 mg/Kg and remaining significant throughout 3 hr of observation. Putrescine also had antipyretic activity, as it significantly reduced pyrogen-induced fever at a dose level (100 mg/Kg i.p.) ineffective in causing hypothermia in normal rats. The hypothermic and antipyretic effects of putrescine were not associated with any obvious sign of toxicity.
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Putrescine has hypothermic and antipyretic activity, in rats / Genedani, Susanna; Bernardi, Mara; Tagliavini, S; Bertolini, Alfio. - In: LIFE SCIENCES. - ISSN 0024-3205. - STAMPA. - 38:(1986), pp. 1293-1298.
Genedani, Susanna; Bernardi, Mara; Tagliavini, S; Bertolini, Alfio
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/742909
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