Laser Doppler flowmetry (LDF) is a technique used to measure relative average velocity, number and flux (number times velocity) of red blood cells in vessels or capillaries. In this study, the effect of topical timolol on the choroidal circulation was investigated in 12 healthy subjects. Maximum velocity of red blood cells and volumetric blood flow rate in sub-foveal choroids are determined in each eye just before instillation of drops and then every 30 min upto 2 hours. Average intraocular pressure (IOP) decreased significantly in the timolol-treated eyes compared to that of placebo-treated eyes. Nevertheless no significant differences in choroidal blood hemodynamic between timolol and placebo-treated eyes were observed.
Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry / Nithiyanantham, Palanisamy; Rovati, Luigi; Mauro, Cellini; Corrado, Gizzi; Ernesto, Strobbe; Emilio, Campos; Charles E., Riva. - STAMPA. - 7885:(2011), pp. 78850E-78850E. (Intervento presentato al convegno SPIE Photonic West tenutosi a San Francisco, CA, usa nel 22–24 January 2011) [10.1117/12.874495].
Effect of timolol on sub-foveal choroidal blood flow using laser Doppler flowmetry
ROVATI, Luigi;
2011
Abstract
Laser Doppler flowmetry (LDF) is a technique used to measure relative average velocity, number and flux (number times velocity) of red blood cells in vessels or capillaries. In this study, the effect of topical timolol on the choroidal circulation was investigated in 12 healthy subjects. Maximum velocity of red blood cells and volumetric blood flow rate in sub-foveal choroids are determined in each eye just before instillation of drops and then every 30 min upto 2 hours. Average intraocular pressure (IOP) decreased significantly in the timolol-treated eyes compared to that of placebo-treated eyes. Nevertheless no significant differences in choroidal blood hemodynamic between timolol and placebo-treated eyes were observed.
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