Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.

Isodicentric X chromosome in myeloproliferative disorders / Temperani, Paola; Zucchini, Patrizia; Emilia, Giovanni; Sacchi, Stefano; Selleri, L; Torelli, Umberto. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 81:(1989), pp. 152-154.

Isodicentric X chromosome in myeloproliferative disorders.

TEMPERANI, Paola;ZUCCHINI, Patrizia;EMILIA, Giovanni;SACCHI, Stefano;TORELLI, Umberto
1989

Abstract

Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
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Isodicentric X chromosome in myeloproliferative disorders / Temperani, Paola; Zucchini, Patrizia; Emilia, Giovanni; Sacchi, Stefano; Selleri, L; Torelli, Umberto. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 81:(1989), pp. 152-154.
Temperani, Paola; Zucchini, Patrizia; Emilia, Giovanni; Sacchi, Stefano; Selleri, L; Torelli, Umberto
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11380/742126
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