Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
Isodicentric X chromosome in myeloproliferative disorders / Temperani, Paola; Zucchini, Patrizia; Emilia, Giovanni; Sacchi, Stefano; Selleri, L; Torelli, Umberto. - In: ACTA HAEMATOLOGICA. - ISSN 0001-5792. - STAMPA. - 81:(1989), pp. 152-154.
Isodicentric X chromosome in myeloproliferative disorders.
TEMPERANI, Paola;ZUCCHINI, Patrizia;EMILIA, Giovanni;SACCHI, Stefano;TORELLI, Umberto
1989
Abstract
Two further cases of acquired isodicentric (X)(q13) chromosome in patients with myeloproliferative disorders are reported. One patient had a primary myelofibrosis and the other a chronic myelogenous leukemia. DNA replication study demonstrated that both abnormal X chromosomes were late replicating in all cells examined. The inactive condition of idic(X)(q13) seems to be indicative of a selective advantage for a cell carrying this alteration.
Pubblicazioni consigliate
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris
