Immediate and controlled release systems were prepared fitting a fast dissolution tablet in the hole of perforated matrices coated on all the surface excepting the hole. The release from the systems of a non steroidalanti-inflammatory drug, diclofenac sodium, was investigated both in water and in gastro-intestinal simulated flluids. A constant drug release was achieved after the complete dissolution of the tablet fitted in the hole. The dissolution of the initial dose was affected by the pH of the simulated gastric fluid. However, as the comparison with a sustained commercial product showed, a higher amount of drug was available from the system in thefirst 150 min.

A hydroxypropylcellulose (HPC) system for the immediate and controlled release of diclofenac sodium / Vandelli, Maria Angela; Leo, Eliana Grazia; Forni, Flavio. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - STAMPA. - 41:(1995), pp. 262-265.

A hydroxypropylcellulose (HPC) system for the immediate and controlled release of diclofenac sodium

VANDELLI, Maria Angela;LEO, Eliana Grazia;FORNI, Flavio
1995

Abstract

Immediate and controlled release systems were prepared fitting a fast dissolution tablet in the hole of perforated matrices coated on all the surface excepting the hole. The release from the systems of a non steroidalanti-inflammatory drug, diclofenac sodium, was investigated both in water and in gastro-intestinal simulated flluids. A constant drug release was achieved after the complete dissolution of the tablet fitted in the hole. The dissolution of the initial dose was affected by the pH of the simulated gastric fluid. However, as the comparison with a sustained commercial product showed, a higher amount of drug was available from the system in thefirst 150 min.
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A hydroxypropylcellulose (HPC) system for the immediate and controlled release of diclofenac sodium / Vandelli, Maria Angela; Leo, Eliana Grazia; Forni, Flavio. - In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. - ISSN 0939-6411. - STAMPA. - 41:(1995), pp. 262-265.
Vandelli, Maria Angela; Leo, Eliana Grazia; Forni, Flavio
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/741969
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