(RS)-2-(4-isobutylphenyl)-propiohydroxamic acid is a non-steroidal anti-inflammatory drug, which forms a equimolecular complex with beta–cyclodextrin, thus increasing the solubilization and the rate of dissolutono f the drug. The inclusion complex in aqueous solution and in solid phase, was studied by solubility methods, spectroscopy (UV, IR, 1H NMR), thermal analysis (DSC, TG). X-ray diffractometry and paper chromatography (PC). Rsults confirmed the formation of this complex
Formation of inclusion complex between the non-steroidal anti-inflammatory drug (RS)-2-(4-isobutylphenyl)-propiohydroxamic acid and beta–cyclodextrin / G., Mazzi; F. F., Vincieri; Forni, Flavio; N., Mulinacci; S., Celli. - In: ACTA PHARMACEUTICA TECHNOLOGICA. - ISSN 0340-3157. - STAMPA. - 34:(1988), pp. 17-21.
Formation of inclusion complex between the non-steroidal anti-inflammatory drug (RS)-2-(4-isobutylphenyl)-propiohydroxamic acid and beta–cyclodextrin
FORNI, Flavio;
1988
Abstract
(RS)-2-(4-isobutylphenyl)-propiohydroxamic acid is a non-steroidal anti-inflammatory drug, which forms a equimolecular complex with beta–cyclodextrin, thus increasing the solubilization and the rate of dissolutono f the drug. The inclusion complex in aqueous solution and in solid phase, was studied by solubility methods, spectroscopy (UV, IR, 1H NMR), thermal analysis (DSC, TG). X-ray diffractometry and paper chromatography (PC). Rsults confirmed the formation of this complex
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