Background: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions. Aims of the study: To evaluate microscopic changes occurring in positive patch test reactions. Methods: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy. Results: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena. Conclusion: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction. © 2011 John Wiley & Sons A/S.
Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy / Ardigò, M; Longo, Caterina; Cristaudo, A; Berardesca, E; Pellacani, Giovanni. - In: SKIN RESEARCH AND TECHNOLOGY. - ISSN 1600-0846. - STAMPA. - 18:1(2012), pp. 61-63. [10.1111/j.1600-0846.2011.00531.x]
Evaluation of allergic vesicular reaction to patch test using in vivo confocal microscopy
LONGO, Caterina;PELLACANI, Giovanni
2012
Abstract
Background: Confocal microscopy has been successfully applied both in oncologic and inflammatory diseases. In particular, it has been proved as a useful tool for the in vivo detection of microscopical changes occurring in allergic reactions. Aims of the study: To evaluate microscopic changes occurring in positive patch test reactions. Methods: Eight patients with history of allergic dermatitis and positive patch test reaction were analysed by means of confocal microscopy. Results: Confocal microscopy showed the presence of spongiotic vesicle preferentially localized around the adnexal ducts that appeared to be in the middle of the spongiotic phenomena. Conclusion: Confocal microscopy offered for the first time new insight into vesicle formation and development, showing that adnexal ducts can play a role in allergic reaction. © 2011 John Wiley & Sons A/S.Pubblicazioni consigliate
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