INTRODUCTION: Patients affected by thin melanomas (≤1mm) generally have a good prognosis; however, some have a recurrence and eventually die of the disease. The seventh edition of the American Joint Committee on Cancer (AJCC) melanoma staging system, introduced mitotic rate (MR) as one of the primary criteria for staging thin melanoma. MATERIALS AND METHODS: In this study, we sought to determine the prognostic value of mitotic rate in a retrospective cohort of localized primary cutaneous melanoma patients. RESULTS: In total, 286 cases of pT1 primary malignant melanoma occurring in the period 2003-2008 were evaluated. Mitotic counts were re-assessed on standard sections of cases without mitosis and with at least 1 mitosis at diagnosis; 5-year follow-up and recurrence-free survival were available for all patients. Of the 56 radically treated pT1b melanoma patients, 4 (7.1%) had recurrent disease. These data support the efficacy of the incorporation of mitogenicity into AJCC staging for localized cutaneous melanoma and indicate the difficulties in the accuracy and reproducibility of the mitotic count system.

Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients / Ponti, Giovanni; A., Pollio; A. M., Cesinaro; Pellacani, Giovanni; Magnoni, Cristina; Seidenari, Stefania. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - STAMPA. - 36:(2012), pp. 303-305. [10.1016/j.canep.2011.11.003]

Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients

PONTI, Giovanni;PELLACANI, Giovanni;MAGNONI, Cristina;SEIDENARI, Stefania
2012

Abstract

INTRODUCTION: Patients affected by thin melanomas (≤1mm) generally have a good prognosis; however, some have a recurrence and eventually die of the disease. The seventh edition of the American Joint Committee on Cancer (AJCC) melanoma staging system, introduced mitotic rate (MR) as one of the primary criteria for staging thin melanoma. MATERIALS AND METHODS: In this study, we sought to determine the prognostic value of mitotic rate in a retrospective cohort of localized primary cutaneous melanoma patients. RESULTS: In total, 286 cases of pT1 primary malignant melanoma occurring in the period 2003-2008 were evaluated. Mitotic counts were re-assessed on standard sections of cases without mitosis and with at least 1 mitosis at diagnosis; 5-year follow-up and recurrence-free survival were available for all patients. Of the 56 radically treated pT1b melanoma patients, 4 (7.1%) had recurrent disease. These data support the efficacy of the incorporation of mitogenicity into AJCC staging for localized cutaneous melanoma and indicate the difficulties in the accuracy and reproducibility of the mitotic count system.
2012
36
303
305
Value and prognostic significance of mitotic rate in a retrospective series of pT1 cutaneous malignant melanoma patients / Ponti, Giovanni; A., Pollio; A. M., Cesinaro; Pellacani, Giovanni; Magnoni, Cristina; Seidenari, Stefania. - In: CANCER EPIDEMIOLOGY. - ISSN 1877-7821. - STAMPA. - 36:(2012), pp. 303-305. [10.1016/j.canep.2011.11.003]
Ponti, Giovanni; A., Pollio; A. M., Cesinaro; Pellacani, Giovanni; Magnoni, Cristina; Seidenari, Stefania
File in questo prodotto:
File Dimensione Formato  
value2011cancer epidemiology.pdf

Solo gestori archivio

Tipologia: Versione pubblicata dall'editore
Dimensione 217.01 kB
Formato Adobe PDF
217.01 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/741768
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 10
  • ???jsp.display-item.citation.isi??? 10
social impact