The peripharal typo benzodiazepine receptor (PBR) was described as another class of binding sites for benzodiazepines distinct from the central benzodiazepine receptor (CBR). In our study we investigated the presence of nuclear PBR in different hepatic tumor cell lines with ragards to binding to [3H]PK11195 and protein analysis. The results obtained indicated that the nuclear PBR density correlates inversely with cell doubling time.
Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation / Geminiani, Elisa; Corsi, Lorenzo; Avallone, Rossella; Baraldi, Mario. - STAMPA. - 1:(2005), pp. 69-69. (Intervento presentato al convegno 32 Congresso Nazionale della Società Italiana di Farmacologia tenutosi a Napoli nel 1-4 giugno 2005).
Nuclear location-dependent role of peripheral benzodiazepine receptor (PBR) in hepatic tumoral cell lines proliferation
GEMINIANI, Elisa;CORSI, Lorenzo;AVALLONE, Rossella;BARALDI, Mario
2005
Abstract
The peripharal typo benzodiazepine receptor (PBR) was described as another class of binding sites for benzodiazepines distinct from the central benzodiazepine receptor (CBR). In our study we investigated the presence of nuclear PBR in different hepatic tumor cell lines with ragards to binding to [3H]PK11195 and protein analysis. The results obtained indicated that the nuclear PBR density correlates inversely with cell doubling time.
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