Human herpesvirus-6 (HHV-6), like all the other herpes viruses, remains latent in host cells after primary infection but can be reactivated In immuno-compromised patients causing fever, skin rash, bone marrow (BM) suppression, pneumonitis, Sinusitis and meningoencephalitis. We describe the case of a man with chronic myelogenous leukemia who developed encephalitis associated with acute graft-versus-host disease two months after a T-cell-depleted mismatched peripheral blood stem cell transplant. Magnetic resonance images of the brain revealed multiple bilateral foci of signal abnormality. HHV-6 was the only pathogen detected in cerebrospinal fluid by PCR. treatment with both ganciclovir and foscarnet was unsuccessful and the patient gradually deteriorated and died. Other cases of HHV-6 encephalitis after bone marrow transplantation are reviewed.

Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor / Tiacci, E; Luppi, Mario; Barozzi, Patrizia; Gurdo, G; Tabilio, A; Ballanti, S; Torelli, Giuseppe; Aversa, F.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 85:(2000), pp. 94-97.

Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor

LUPPI, Mario;BAROZZI, Patrizia;TORELLI, Giuseppe;
2000-01-01

Abstract

Human herpesvirus-6 (HHV-6), like all the other herpes viruses, remains latent in host cells after primary infection but can be reactivated In immuno-compromised patients causing fever, skin rash, bone marrow (BM) suppression, pneumonitis, Sinusitis and meningoencephalitis. We describe the case of a man with chronic myelogenous leukemia who developed encephalitis associated with acute graft-versus-host disease two months after a T-cell-depleted mismatched peripheral blood stem cell transplant. Magnetic resonance images of the brain revealed multiple bilateral foci of signal abnormality. HHV-6 was the only pathogen detected in cerebrospinal fluid by PCR. treatment with both ganciclovir and foscarnet was unsuccessful and the patient gradually deteriorated and died. Other cases of HHV-6 encephalitis after bone marrow transplantation are reviewed.
2000
85
94
97
Fatal herpesvirus-6 encephalitis in a recipient of a T-cell-depleted peripheral blood stem cell transplant from a 3-loci mismatched related donor / Tiacci, E; Luppi, Mario; Barozzi, Patrizia; Gurdo, G; Tabilio, A; Ballanti, S; Torelli, Giuseppe; Aversa, F.. - In: HAEMATOLOGICA. - ISSN 0390-6078. - STAMPA. - 85:(2000), pp. 94-97.
Tiacci, E; Luppi, Mario; Barozzi, Patrizia; Gurdo, G; Tabilio, A; Ballanti, S; Torelli, Giuseppe; Aversa, F.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/7415
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