In rats, the continuous infusion of ACTH-(1-24) into a brain lateral ventricle (0.5 micrograms/h in the volume of 1.11 microliters, for 7 days) caused a significant inhibition of the subsequent behavioural response to the acute intracerebroventricular injection of the same peptide. Tolerance developed to all the most typical signs of the ACTH-induced behavioural syndrome (grooming, stretching, yawning, penile erection, inhibition of food intake), and was associated with a significant increase in the hypothalamic levels of beta-endorphin immunoreactivity.

Tolerance develops to the behavioural effects of ACTH-(1-24) during continuous i.c.v. infusion in rats, and is associated with increased hypothalamic levels of beta-endorphin / A. V., Vergoni; R., Poggioli; Facchinetti, Fabio; C., Bazzani; D., Marrama; A., Bertolini. - In: NEUROPEPTIDES. - ISSN 0143-4179. - STAMPA. - 14:(1989), pp. 93-98.

Tolerance develops to the behavioural effects of ACTH-(1-24) during continuous i.c.v. infusion in rats, and is associated with increased hypothalamic levels of beta-endorphin.

FACCHINETTI, Fabio;
1989-01-01

Abstract

In rats, the continuous infusion of ACTH-(1-24) into a brain lateral ventricle (0.5 micrograms/h in the volume of 1.11 microliters, for 7 days) caused a significant inhibition of the subsequent behavioural response to the acute intracerebroventricular injection of the same peptide. Tolerance developed to all the most typical signs of the ACTH-induced behavioural syndrome (grooming, stretching, yawning, penile erection, inhibition of food intake), and was associated with a significant increase in the hypothalamic levels of beta-endorphin immunoreactivity.
14
93
98
Tolerance develops to the behavioural effects of ACTH-(1-24) during continuous i.c.v. infusion in rats, and is associated with increased hypothalamic levels of beta-endorphin / A. V., Vergoni; R., Poggioli; Facchinetti, Fabio; C., Bazzani; D., Marrama; A., Bertolini. - In: NEUROPEPTIDES. - ISSN 0143-4179. - STAMPA. - 14:(1989), pp. 93-98.
A. V., Vergoni; R., Poggioli; Facchinetti, Fabio; C., Bazzani; D., Marrama; A., Bertolini
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/740732
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