The present experiment was designed to study whether or not prior exposure to inescapable shock is accompanied by sex-dependent changes in pituitary and central levels of immunoreactive beta-endorphin, which is proposed to play an important role in opioid analgesia induced by aversive stimulation. Further, the effects of brief reexposure (5 min) to the chamber where inescapable shock was experienced earlier, were established in both sexes. Elevated levels of beta-endorphin were found 24 hours after inescapable shock, in the anterior pituitary of males and in the midbrain periaqueductal gray of both males and females. Reexposure to the experimental chamber only affected beta-endorphin levels if shock had been experienced in this chamber. Reexposure after inescapable shock reduced beta-endorphin content of the arcuate nucleus of males and beta-endorphin content of the periaqueductal gray of males and females. The present results are related to previous findings of sensitization and conditioning of analgesic reactions. The sex differences found in the present experiment are discussed with respect to sex-dependent behavioral consequences of inescapable shock.
|Data di pubblicazione:||1991|
|Titolo:||Pituitary and brain beta-endorphin in male and female rats: effects of shock and cues associated with shock.|
|Autore/i:||F. Farabollini;R. P. Heinsbroek;F. Facchinetti;N. E. van|
|Codice identificativo ISI:||WOS:A1991FJ06900016|
|Codice identificativo Scopus:||2-s2.0-0025729781|
|Citazione:||Pituitary and brain beta-endorphin in male and female rats: effects of shock and cues associated with shock. / F. Farabollini;R. P. Heinsbroek;F. Facchinetti;N. E. van. - In: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. - ISSN 0091-3057. - STAMPA. - 38(1991), pp. 795-799.|
|Tipologia||Articolo su rivista|
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