N1 non-small-cell lung cancer has heterogeneous prognosis in relation to node descriptors. There is no agreement on the ideal type of resection. A new classification of N1 descriptors was proposed in the 7(th) edition of the TNM staging system. A retrospective study was conducted on 384 patients with T1-T3N1 non-small-cell lung cancer who underwent complete pulmonary resection. The prognostic role of N1 descriptors according to the current and new staging systems and type of resection was investigated. The 5-year survival rate was 46\%. Involvement of hilar node stations, multiple stations, and multiple nodes were poor prognostic factors (5-year survival, 33\%, 21\%, and 30\%, respectively), as well as involvement of the hilar zone and multiple zones (5-year survival, 27\% and 23\%, respectively). Pneumonectomy showed significantly better survival rates compared to lobectomy or bilobectomy (5-year survival, 60\% vs. 29\%). Multivariate analysis showed that the number of N1 zones and type of resection were independent prognostic factors. Patients with hilar nodal, multiple-level, or multiple-zone involvement had poor prognosis. Standard lobectomy remains the procedure of choice, but in cases of fixed nodes in the hilar zone, sleeve resection or even pneumonectomy should be considered.

N1 non-small-cell lung cancer. A 20-year surgical experience / C., Casali; Stefani, Alessandro; Morandi, Uliano. - In: ASIAN CARDIOVASCULAR AND THORACIC ANNALS. - ISSN 0218-4923. - STAMPA. - 19:3-4(2011), pp. 217-224. [10.1177/0218492311407904]

N1 non-small-cell lung cancer. A 20-year surgical experience.

STEFANI, Alessandro;MORANDI, Uliano
2011

Abstract

N1 non-small-cell lung cancer has heterogeneous prognosis in relation to node descriptors. There is no agreement on the ideal type of resection. A new classification of N1 descriptors was proposed in the 7(th) edition of the TNM staging system. A retrospective study was conducted on 384 patients with T1-T3N1 non-small-cell lung cancer who underwent complete pulmonary resection. The prognostic role of N1 descriptors according to the current and new staging systems and type of resection was investigated. The 5-year survival rate was 46\%. Involvement of hilar node stations, multiple stations, and multiple nodes were poor prognostic factors (5-year survival, 33\%, 21\%, and 30\%, respectively), as well as involvement of the hilar zone and multiple zones (5-year survival, 27\% and 23\%, respectively). Pneumonectomy showed significantly better survival rates compared to lobectomy or bilobectomy (5-year survival, 60\% vs. 29\%). Multivariate analysis showed that the number of N1 zones and type of resection were independent prognostic factors. Patients with hilar nodal, multiple-level, or multiple-zone involvement had poor prognosis. Standard lobectomy remains the procedure of choice, but in cases of fixed nodes in the hilar zone, sleeve resection or even pneumonectomy should be considered.
2011
19
3-4
217
224
N1 non-small-cell lung cancer. A 20-year surgical experience / C., Casali; Stefani, Alessandro; Morandi, Uliano. - In: ASIAN CARDIOVASCULAR AND THORACIC ANNALS. - ISSN 0218-4923. - STAMPA. - 19:3-4(2011), pp. 217-224. [10.1177/0218492311407904]
C., Casali; Stefani, Alessandro; Morandi, Uliano
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/740362
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