In order to evaluate the nature and prevalence of audiovestibular disturbances in mixed cryoglobulinaemia (MC), 32 consecutive MC patients were studied by a wide audiological and vestibular examination. Pure tone audiometry, impedance audiometry, brainstem response audiometry and vestibular function were performed. Patients with a previous history of ear damage due to other well-known agents were excluded from the study. In MC patients we found a rather frequent audiovestibular involvement (34.3%). Bilateral sensorineural hearing loss was found in seven MC patients (22%) and altered vestibular function test values in other seven subjects (22%). Moreover, anamnestic and clinical data revealed a high incidence of benign positional paroxysmal vertigo in our MC series. We can suppose that immune complex-mediated microvascular involvement of the labyrinthine vessels may be responsible for inner ear damage in MC. Thus, audiovestibular disturbances may be included among various organ involvement of the MC.
Inner ear involvement in mixed cryoglobulinaemia patients / Berrettini, S; Ferri, Clodoveo; La Civita, L; Segnini, G; Lombardini, F; Bruschini, P; Longombardo, G; Sellari Franceschini, S.. - In: BRITISH JOURNAL OF RHEUMATOLOGY. - ISSN 0263-7103. - STAMPA. - 34:(1995), pp. 370-374.