A low dose of transdermally administered 17 B-estradiol promptly improved a severe, treatment-unresponsive, cardiac arrhythmia initiated after the menopause in a woman with type-II familial hyperlipoproteinemia. The same treatment normalized the hypertension initiated after ovariectomy, in a woman who was only poorly controlled by anti-hypertensive drugs. These two cases are the first clear report of cardiovascular therapeutic properties of transdermal estradiol via mechanisms independent of lipoprotein modifications.
Lipid-independent therapeutic properties of transdermal 17 B-estradiol on cardiovascular diseases / Cagnacci, Angelo; R., Soldani; E., Puccini; P., Fioretti; G. B., Melis. - In: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. - ISSN 0001-6349. - STAMPA. - 71:(1992), pp. 639-641.
Lipid-independent therapeutic properties of transdermal 17 B-estradiol on cardiovascular diseases.
CAGNACCI, Angelo;
1992
Abstract
A low dose of transdermally administered 17 B-estradiol promptly improved a severe, treatment-unresponsive, cardiac arrhythmia initiated after the menopause in a woman with type-II familial hyperlipoproteinemia. The same treatment normalized the hypertension initiated after ovariectomy, in a woman who was only poorly controlled by anti-hypertensive drugs. These two cases are the first clear report of cardiovascular therapeutic properties of transdermal estradiol via mechanisms independent of lipoprotein modifications.
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