To evaluate whether dopaminergic treatment may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on luteinizing hormone (LH) secretion were studied in 5 postmenopausal women either before or after chronic administration of the dopaminergic drug bromocriptine (BCT; 5 mg/day for 30 days). BCT administration did not modify mean plasma LH levels. Before treatment naloxone infusion did not induce any significant modification of LH secretion. Conversely, after chronic BCT administration naloxone induced a significant (p less than 0.05) increase in plasma LH levels. The LH response to naloxone was significantly (p less than 0.001) higher than that observed before BCT. The present data show that chronic BCT administration restores the LH response to naloxone in postmenopausal women. Therefore, these results seem to demonstrate that BCT administration can enhance opioid activity, suggesting an involvement of the endogenous opioid system in dopaminergic modulation of gonadotropin release.

Chronic bromocriptine administration restores luteinizing hormone response to naloxone in postmenopausal women / G. B., Melis; Cagnacci, Angelo; M., Gambacciani; A. M., Paoletti; T., Caffi; P., Fioretti. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - STAMPA. - 47:(1988), pp. 159-163.

Chronic bromocriptine administration restores luteinizing hormone response to naloxone in postmenopausal women.

CAGNACCI, Angelo;
1988

Abstract

To evaluate whether dopaminergic treatment may modify endogenous opioid activity at the hypothalamic-pituitary level, the effects of naloxone infusion (1.6 mg/h for 4 h) on luteinizing hormone (LH) secretion were studied in 5 postmenopausal women either before or after chronic administration of the dopaminergic drug bromocriptine (BCT; 5 mg/day for 30 days). BCT administration did not modify mean plasma LH levels. Before treatment naloxone infusion did not induce any significant modification of LH secretion. Conversely, after chronic BCT administration naloxone induced a significant (p less than 0.05) increase in plasma LH levels. The LH response to naloxone was significantly (p less than 0.001) higher than that observed before BCT. The present data show that chronic BCT administration restores the LH response to naloxone in postmenopausal women. Therefore, these results seem to demonstrate that BCT administration can enhance opioid activity, suggesting an involvement of the endogenous opioid system in dopaminergic modulation of gonadotropin release.
47
159
163
Chronic bromocriptine administration restores luteinizing hormone response to naloxone in postmenopausal women / G. B., Melis; Cagnacci, Angelo; M., Gambacciani; A. M., Paoletti; T., Caffi; P., Fioretti. - In: NEUROENDOCRINOLOGY. - ISSN 0028-3835. - STAMPA. - 47:(1988), pp. 159-163.
G. B., Melis; Cagnacci, Angelo; M., Gambacciani; A. M., Paoletti; T., Caffi; P., Fioretti
File in questo prodotto:
File Dimensione Formato  
NEUROENDOCRINOLOGY1988.pdf

non disponibili

Tipologia: Abstract
Dimensione 2.54 MB
Formato Adobe PDF
2.54 MB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/740269
Citazioni
  • ???jsp.display-item.citation.pmc??? 0
  • Scopus 19
  • ???jsp.display-item.citation.isi??? 18
social impact