An epidemic of pediatric obesity has occurred across the world in recent years. There are subgroups within the population at high-risk of becoming obese and especially of having experience of precocious cardiovascular and metabolic co-morbidities of obesity. One of these subgroups comprises patients treated for childhood cancers and namely survivors of craniopharyngioma. The high incidence of obesity in this group makes these patients an important disease model to better understand the metabolic disturbances and the mechanisms of weight gain among cancer survivors. The hypothalamic-pituitary axis damage secondary to cancer therapies or to primary tumor location affect long-term outcomes. Nevertheless, the aetiology of obesity in craniopharyngioma is not yet fully understood. The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population.

Obesity and craniopharyngioma / Iughetti, Lorenzo; Bruzzi, Patrizia. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - ELETTRONICO. - 37:1(2011), pp. 38-38. [10.1186/1824-7288-37-38]

Obesity and craniopharyngioma.

IUGHETTI, Lorenzo;BRUZZI, Patrizia
2011

Abstract

An epidemic of pediatric obesity has occurred across the world in recent years. There are subgroups within the population at high-risk of becoming obese and especially of having experience of precocious cardiovascular and metabolic co-morbidities of obesity. One of these subgroups comprises patients treated for childhood cancers and namely survivors of craniopharyngioma. The high incidence of obesity in this group makes these patients an important disease model to better understand the metabolic disturbances and the mechanisms of weight gain among cancer survivors. The hypothalamic-pituitary axis damage secondary to cancer therapies or to primary tumor location affect long-term outcomes. Nevertheless, the aetiology of obesity in craniopharyngioma is not yet fully understood. The present review has the aim of summarizing the published data and examining the most accepted mechanisms and main predisposing factors related to weight gain in this particular population.
2011
37
1
38
38
Obesity and craniopharyngioma / Iughetti, Lorenzo; Bruzzi, Patrizia. - In: THE ITALIAN JOURNAL OF PEDIATRICS. - ISSN 1824-7288. - ELETTRONICO. - 37:1(2011), pp. 38-38. [10.1186/1824-7288-37-38]
Iughetti, Lorenzo; Bruzzi, Patrizia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/739830
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