To assess the prognostic value of tumor proliferative activity, 89 patients with operable non-small cell lung cancer were studied. Tumor samples were obtained during surgery and cell kinetics were analyzed by the in vitro thymidine labelling index (TLI). The overall median TLI (2.9) was used to identify two subsets of patients with high and low proliferating tumors. In univariate analysis survival was significantly longer in patients with lower TLI (P = 0.047) and with stage I-II (P = 0.003) and T1-T2 tumors (P = 0.043). In multivariate analysis, stage was the most important prognostic parameter (P = 0.004). The risk of death for patients with TLI higher than 2.9 was increased (hazard ratio = 2.01, CI = 0.96-4.27).

Thymidine labelling index as prognostic factor in resected non-small cell lung cancer / A., Alama; M., Costantini; L., Repetto; Conte, Pierfranco; J., Serrano; A., Nicolin; F., Barbieri; A., Ardizzoni; P., Bruzzi. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - STAMPA. - 26:(1990), pp. 622-625.

Thymidine labelling index as prognostic factor in resected non-small cell lung cancer.

CONTE, Pierfranco;
1990

Abstract

To assess the prognostic value of tumor proliferative activity, 89 patients with operable non-small cell lung cancer were studied. Tumor samples were obtained during surgery and cell kinetics were analyzed by the in vitro thymidine labelling index (TLI). The overall median TLI (2.9) was used to identify two subsets of patients with high and low proliferating tumors. In univariate analysis survival was significantly longer in patients with lower TLI (P = 0.047) and with stage I-II (P = 0.003) and T1-T2 tumors (P = 0.043). In multivariate analysis, stage was the most important prognostic parameter (P = 0.004). The risk of death for patients with TLI higher than 2.9 was increased (hazard ratio = 2.01, CI = 0.96-4.27).
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Thymidine labelling index as prognostic factor in resected non-small cell lung cancer / A., Alama; M., Costantini; L., Repetto; Conte, Pierfranco; J., Serrano; A., Nicolin; F., Barbieri; A., Ardizzoni; P., Bruzzi. - In: EUROPEAN JOURNAL OF CANCER. - ISSN 0959-8049. - STAMPA. - 26:(1990), pp. 622-625.
A., Alama; M., Costantini; L., Repetto; Conte, Pierfranco; J., Serrano; A., Nicolin; F., Barbieri; A., Ardizzoni; P., Bruzzi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/739676
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