The management of patients with epithelial ovarian cancer with no or minimal residual disease at second-look laparotomy after aggressive surgery and platinum-based chemotherapy has not been definitively established. We report the results of a randomized study comparing three more courses of the same chemotherapy inducing the response (21 patients) with whole-abdomen radiotherapy (20 patients). Thirty-eight patients responded to first-line chemotherapy and three had stabilization of disease. In eight patients tumor debulking was performed at second-look laparotomy. No severe toxic effects were noted in both arms. Bowel obstruction occurred in one patient treated with radiotherapy. At a median follow-up of 22 months, 11 of 20 patients in the radiotherapy arm and 6 of 21 in the chemotherapy arm progressed and 9 and 3 patients died, respectively. Although the number of randomized patients is small we stopped the trial because of the survival and progression-free survival advantage of chemotherapy-treated patients.

Chemotherapy versus radiotherapy in the management of ovarian cancer patients with pathological complete response or minimal residual disease at second look / M., Bruzzone; L., Repetto; S., Chiara; E., Campora; Conte, Pierfranco; M., Orsatti; V., Vitale; A., Rubagotti; R., Rosso. - In: GYNECOLOGIC ONCOLOGY. - ISSN 0090-8258. - STAMPA. - 38:(1990), pp. 392-395.

Chemotherapy versus radiotherapy in the management of ovarian cancer patients with pathological complete response or minimal residual disease at second look.

CONTE, Pierfranco;
1990-01-01

Abstract

The management of patients with epithelial ovarian cancer with no or minimal residual disease at second-look laparotomy after aggressive surgery and platinum-based chemotherapy has not been definitively established. We report the results of a randomized study comparing three more courses of the same chemotherapy inducing the response (21 patients) with whole-abdomen radiotherapy (20 patients). Thirty-eight patients responded to first-line chemotherapy and three had stabilization of disease. In eight patients tumor debulking was performed at second-look laparotomy. No severe toxic effects were noted in both arms. Bowel obstruction occurred in one patient treated with radiotherapy. At a median follow-up of 22 months, 11 of 20 patients in the radiotherapy arm and 6 of 21 in the chemotherapy arm progressed and 9 and 3 patients died, respectively. Although the number of randomized patients is small we stopped the trial because of the survival and progression-free survival advantage of chemotherapy-treated patients.
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Chemotherapy versus radiotherapy in the management of ovarian cancer patients with pathological complete response or minimal residual disease at second look / M., Bruzzone; L., Repetto; S., Chiara; E., Campora; Conte, Pierfranco; M., Orsatti; V., Vitale; A., Rubagotti; R., Rosso. - In: GYNECOLOGIC ONCOLOGY. - ISSN 0090-8258. - STAMPA. - 38:(1990), pp. 392-395.
M., Bruzzone; L., Repetto; S., Chiara; E., Campora; Conte, Pierfranco; M., Orsatti; V., Vitale; A., Rubagotti; R., Rosso
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/739655
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