Chemotherapy is a major tool for metastatic breast cancer treatment. In this study, a series of 316 patients have been analyzed to evaluate the time needed to reach tumor response by means of combination chemotherapy. Twenty-five percent of patients responded within 3 months and virtually all responses occurred within 7.5 months. The time curves of response (any) and best response are superimposable. A subset analysis has shown that the following pretreatment characteristics predict a significantly longer time to response: prior exposure to adjuvant chemotherapy, nodal positivity at diagnosis, no previous endocrine treatment and osseous metastases.
Analysis of time to response to chemotherapy in 316 metastatic breast cancer patients / P., Pronzato; G., Bertelli; G., Gardin; A., Rubagotti; Conte, Pierfranco; R., Rosso. - In: ONCOLOGY. - ISSN 0030-2414. - STAMPA. - 50:(1993), pp. 460-465.
Analysis of time to response to chemotherapy in 316 metastatic breast cancer patients.
CONTE, Pierfranco;
1993
Abstract
Chemotherapy is a major tool for metastatic breast cancer treatment. In this study, a series of 316 patients have been analyzed to evaluate the time needed to reach tumor response by means of combination chemotherapy. Twenty-five percent of patients responded within 3 months and virtually all responses occurred within 7.5 months. The time curves of response (any) and best response are superimposable. A subset analysis has shown that the following pretreatment characteristics predict a significantly longer time to response: prior exposure to adjuvant chemotherapy, nodal positivity at diagnosis, no previous endocrine treatment and osseous metastases.
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