The objective of the present study was prospectively to evaluate the role of nitric oxide (NO) in modulating intratesticular blood flow and sperm function. A total of 56 males, undergoing assisted reproduction, were divided into three groups according to semen analysis: (i) normozoospermic (n = 16); (ii) oligozoospermic (n = 21); and (iii) azoospermic (n = 19). All the subjects were submitted to hormone analysis [luteinizing hormone, follicle stimulating hormone (FSH), growth hormone, testosterone, androstenedione, insulin], and to ultrasonographic (testicular volume) and Doppler (transmediastinal artery) evaluations. Plasma and seminal plasma nitrite/nitrate concentrations, and plasma insulin-like growth factor-I were assayed. All 56 patients completed the study. In normozoospermic patients, significantly greater testicular volume, lower transmediastinal resistances, and higher seminal plasma nitrite/nitrate concentrations were observed in comparison with both oligo- and azoospermic subjects. Testicular volume was inversely correlated with plasma FSH (r = -0.589; P = 0.005) and pulsatility index of transmediastinal artery (r = -0.402; P = 0.049). Furthermore, the seminal plasma nitrite/nitrate concentrations were inversely correlated with pulsatility index of transmediastinal artery (r = -0.511; P = 0.015). It was concluded that NO is involved in vascular modulation of testicular vessels and ultimately in sperm output.

Seminal plasma nitrite/nitrate and intratesticular Doppler flow in fertile and infertile subjects / C., Battaglia; S., Giulini; G., Regnani; R. D., Girolamo; S., Paganelli; Facchinetti, Fabio; Volpe, Annibale. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 15:(2000), pp. 2554-2558. [10.1093/humrep/15.12.2554]

Seminal plasma nitrite/nitrate and intratesticular Doppler flow in fertile and infertile subjects

FACCHINETTI, Fabio;VOLPE, Annibale
2000

Abstract

The objective of the present study was prospectively to evaluate the role of nitric oxide (NO) in modulating intratesticular blood flow and sperm function. A total of 56 males, undergoing assisted reproduction, were divided into three groups according to semen analysis: (i) normozoospermic (n = 16); (ii) oligozoospermic (n = 21); and (iii) azoospermic (n = 19). All the subjects were submitted to hormone analysis [luteinizing hormone, follicle stimulating hormone (FSH), growth hormone, testosterone, androstenedione, insulin], and to ultrasonographic (testicular volume) and Doppler (transmediastinal artery) evaluations. Plasma and seminal plasma nitrite/nitrate concentrations, and plasma insulin-like growth factor-I were assayed. All 56 patients completed the study. In normozoospermic patients, significantly greater testicular volume, lower transmediastinal resistances, and higher seminal plasma nitrite/nitrate concentrations were observed in comparison with both oligo- and azoospermic subjects. Testicular volume was inversely correlated with plasma FSH (r = -0.589; P = 0.005) and pulsatility index of transmediastinal artery (r = -0.402; P = 0.049). Furthermore, the seminal plasma nitrite/nitrate concentrations were inversely correlated with pulsatility index of transmediastinal artery (r = -0.511; P = 0.015). It was concluded that NO is involved in vascular modulation of testicular vessels and ultimately in sperm output.
2000
15
2554
2558
Seminal plasma nitrite/nitrate and intratesticular Doppler flow in fertile and infertile subjects / C., Battaglia; S., Giulini; G., Regnani; R. D., Girolamo; S., Paganelli; Facchinetti, Fabio; Volpe, Annibale. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - STAMPA. - 15:(2000), pp. 2554-2558. [10.1093/humrep/15.12.2554]
C., Battaglia; S., Giulini; G., Regnani; R. D., Girolamo; S., Paganelli; Facchinetti, Fabio; Volpe, Annibale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/739448
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