The effect of Tumor Necrosis Factor (TNF) on VP16 or VM26 cytotoxicity was studied in a human glioblastoma cell line T98G, which expresses TNF-receptors. Although T98G cells did not produce TNF endogenously they were resistant to the cytolytic effect of TNF. T98G cells were also moderately sensitive to the action of VP16 or VM26. TNF given at 1000 U/ml was able to increase the cell drug-sensitivity significantly. This effect was due to an increase in the VP 16-induced cleavable-complexes by TNF. These findings suggest that TNF specifically sensitizes human glioma T98G cells to the effects of VP 16 of VM26.

Sensitization of human glioblastoma T98G cells to VP16 and VM26 by human tumor necrosis factor / P., Morgavi; G., Cimoli; C., Ottoboni; A., Michelotti; Conte, Pierfranco; S., Parodi; P., Russo. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 15:(1995), pp. 1423-1428.

Sensitization of human glioblastoma T98G cells to VP16 and VM26 by human tumor necrosis factor.

CONTE, Pierfranco;
1995

Abstract

The effect of Tumor Necrosis Factor (TNF) on VP16 or VM26 cytotoxicity was studied in a human glioblastoma cell line T98G, which expresses TNF-receptors. Although T98G cells did not produce TNF endogenously they were resistant to the cytolytic effect of TNF. T98G cells were also moderately sensitive to the action of VP16 or VM26. TNF given at 1000 U/ml was able to increase the cell drug-sensitivity significantly. This effect was due to an increase in the VP 16-induced cleavable-complexes by TNF. These findings suggest that TNF specifically sensitizes human glioma T98G cells to the effects of VP 16 of VM26.
1995
15
1423
1428
Sensitization of human glioblastoma T98G cells to VP16 and VM26 by human tumor necrosis factor / P., Morgavi; G., Cimoli; C., Ottoboni; A., Michelotti; Conte, Pierfranco; S., Parodi; P., Russo. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - STAMPA. - 15:(1995), pp. 1423-1428.
P., Morgavi; G., Cimoli; C., Ottoboni; A., Michelotti; Conte, Pierfranco; S., Parodi; P., Russo
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

Licenza Creative Commons
I metadati presenti in IRIS UNIMORE sono rilasciati con licenza Creative Commons CC0 1.0 Universal, mentre i file delle pubblicazioni sono rilasciati con licenza Attribuzione 4.0 Internazionale (CC BY 4.0), salvo diversa indicazione.
In caso di violazione di copyright, contattare Supporto Iris

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11380/739398
Citazioni
  • ???jsp.display-item.citation.pmc??? 2
  • Scopus 8
  • ???jsp.display-item.citation.isi??? 9
social impact