We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.
The system epilepsies: a pathophysiological hypothesis / Avanzini, G; Manganotti, P; Meletti, Stefano; Moshé, Sl; Panzica, F; Wolf, P; Capovilla, G.. - In: EPILEPSIA. - ISSN 0013-9580. - STAMPA. - 53:5(2012), pp. 771-778. [10.1111/j.1528-1167.2012.03462.x]
The system epilepsies: a pathophysiological hypothesis.
MELETTI, Stefano;
2012
Abstract
We postulate that "system epilepsies" (SystE) are due to an enduring propensity to generate seizures of functionally characterized brain systems. Data supporting this hypothesis-that some types of epilepsy depend on the dysfunction of specific neural systems-are reviewed. The SystE hypothesis may drive pathophysiologic and clinical studies that can advance our understanding of epilepsies and can open up new therapeutic perspectives.
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